The human blastocyst comprises an inner cell compartment, that gives rise to the fetus and to the yolk sac, surrounded by an epithelial layer of trophoblast cells (trophectoderm, TE) that fulfills the crucial functions of mediating the implantation into the uterus and of forming the placenta. Of note, preimplantation development is prone to failure thus forms a major roadblock to establish successful pregnancy. Also, only 40% of the fertilized egg reaches a blastocyst stage with quality standards during IVF procedures. Despite clinical significance, the mechanisms underlying human blastocyst development remains largely unknown. This is because human embryos are available in limited numbers for the research and are extremely difficult to experimentally manipulate. Thus, the human embryo model that faithfully recapitulates the morphology, cell types, and function will allow us to study early human embryonic development. We have now established a robust and efficient model of human blastocyst from naive human pluripotent stem cells (hPSCs) by triple inhibition of the Hippo, TGF-β, and ERK pathways. I will introduce the four key features of these models that strongly suggests that they faithfully recapitulate several aspects of human blastocyst development.