Achievements

2022

• Imoto, Y.#, Nakamura, T.#, Escolar, G., E., Yoshiwaki, M., Kojima, Y., Yabuta, Y., Katou, Y., Yamamoto, T., Hiraoka, Y., Saitou, M.
  "Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis."
  Life Science Alliance. (2022), [DOI:10.26508/lsa.202201591] [プレスリリース]

• Mizuta, K., Katou, Y., Nakakita, B., Kishine, A., Nosaka, Y., Saito, S., Iwatani, C., Tsuchiya, H., Kawamoto, I., Nakaya, M., Tsukiyama, T., Nagano, M., Kojima, Y., Nakamura, T., Yabuta, Y., Horie, A., Mandai, M., Ohta, H., Saitou, M.
  "Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys."
  The EMBO Journal. (2022), [DOI:10.15252/embj.2022110815] [プレスリリース]

• Tsujihana, K., Tanegashima, K., Santo, Y., Yamada, H., Akazawa, S., Nakao, R., Tominaga, K., Saito, R., Nishito, Y., Hata, R., Nakamura, T., Murai, I., Kono, Y., Sugawa, M., Tanioka, M., Egawa, G., Doi, M.,Isa, T., Kabashima, K., Hara, T., Okamura, H.
  "Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity."
  Proceedings of the National Academy of Sciences. (2022), [DOI:10.1073/pnas.2116027119]

• Watanabe, T*. and Sasaki, E.
  "Efficient Induction of Primate iPS cells using a combination of RNA transfection and chemical compounds"
  Methods in Molecular Biology. (2022), [DOI: 10.1007/7651_2021_373]

2021

• Io, S., Iemura, Y., Takashima, Y*.
  "Optimized protocol for naive human pluripotent stem cell-derived trophoblast induction"
  STAR protocol. (2021), [DOI:10.1016/j.xpro.2021.100921]

• Kishimoto, K., Shimada, A., Shinohara, H., Takahashi, T., Yamada, Y., Higuchi, Y., Yoneda, N., Suemizu, H., Kawai, K., Kurotaki, Y., Hanazawa, K., Takashima, Y., Sasaki, E.
  "Establishment of novel common marmoset embryonic stem cell lines under various conditions."
  Stem Cell Research. (2021), [DOI: 10.1016/j.scr.2021.102252]

• Takahashi, K., Nakamura, M., Okubo, C., Kliesmete, Z., Ohnuki, M., Narita, M., Watanabe, A., Ueda, M., Takashima, Y., Hellmann, I., Yamanaka, S.
  "The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency."
  PLoS Genetics. (2021), [DOI:10.1371/journal.pgen.1009587]

• Kozawa, K., Sekai, M., Ohba, K., Ito, S., Sako, H., Maruyama, T., Kakeno, M., Shirai, T., Kuromiya, K., Kamasaki, T., Kohashi, K., Tanaka, S., Ishikawa, S., Sato, N., Asano, S., Suzuki, H., Tanimura, N., Mukai, Y., Gotoh, N., Tanino, M., Tanaka, S., Natsuga, K., Soga, T., Nakamura, T., Yabuta, Y., Saitou, M., Ito, T., Matsuura, K., Tsunoda, M., Kikumori, T., Iida, T., Mizutani, T., Miyai, Y., Kaibuchi, K., Enomoto, A., Fujita, Y.
  "The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia."
  Current Biology. (2021), [DOI:10.1016/j.cub.2021.04.078]

• Okamoto, I., Nakamura, T., Sasaki, K., Yabuta, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Ema, M., Yamamoto, T., Saitou, M.
  "The X chromosome dosage compensation program during the development of cynomolgus monkeys."
  Science. (2021), [DOI: 10.1126/science.abd8887] [プレスリリース]

• Ishikura, Y., Ohta, H., Sato, T., Murase, Y., Yabuta, Y., Kojima, Y., Yamashiro, C., Nakamura, T., Yamamoto, T., Ogawa. T., Saitou, M.
  "In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells."
  Cell Stem Cell. (2021), [DOI:10.1016/j.stem.2021.08.005] [プレスリリース]

• Jayakumar, V., Nishimura, O., Kadota, K., Hirose, N., Sano, H., Murakawa, Y., Yamamoto, Y., Nakaya, M., Tsukiyama, T., Seita, Y., Nakamura, S., Kawai, J., Sasaki, E., Ema, M., Kuraku, S., Kawaji, H. Sakakibara, Y.
  "Chromosomal-scale de novo genome assemblies of Cynomolgus Macaque and Common Marmoset."
  Scientific Data. (2021), [DOI:10.6084/m9.figshare.14665314]

• Eto, T., Ueda, H., Ito, R., Takahashi, T., Watanabe, T., Goto, M., Sotomaru, Y., Tanaka, N., Takahashi, R.,
  "Establishment of an integrated automated embryonic manipulation system for producing genetically modified mice."
  Scientific Reports. (2021), [DOI:10.1038/s41598-021-91148-9]

• Nakamura, T.*, Fujiwara, K., Saitou, M., and Tsukiyama, T*.
  "Non-human primates as a model for human development."
  Stem Cell Reports. (2021), [DOI: 10.1016/j.stemcr.2021.03.021]

• Io, S., Kabata, M., Iemura, Y., Semi, K., Morone, N., Minagawa, A., Wang, B., Okamoto, I., Nakamura, T., Kojima, Y., Iwatani, C., Tsuchiya, H., Kaswandy, B., Kondoh, E., Kaneko, S., Woltjen, K., Saitou, M., Yamamoto, T., Mandai, M., and Takashima, Y.*
  "Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell."
  Cell Stem Cell. (2021), [DOI:10.1016/j.stem.2021.03.013] [プレスリリース]

• Semi, K., and Takashima, Y*.
  "Pluripotent stem cells for the study of early human embryology."
  Development, Growth & Differentiation. (2021), [DOI: 10.1111/dgd.12715]

• Kojima, Y., Yamashiro, C., Murase, Y., Yabuta, Y., Okamoto, I., Iwatani, C., Tsuchiya, H., Nakaya, M., Tsukiyama, T., Nakamura, T., et al.
  "GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program."
  Life Science Alliance. (2021), [DOI: 10.26508/lsa.202000974]

2022

• 髙島 康弘
  “Modeling in vitro embryonic development using naive human pluripotent stem cells”
  第127回日本解剖学会総会・全国学術集会, 2022/3/28

• Yasuhiro Takashima
  “Modeling in vitro embryonic development using naive human pluripotent stem cells”
  SY-STEM , the Research Institute of Molecular Pathology (IMP)/Institute of Molecular Biotechnology (IMBA), 2022/3/23

• 中村 友紀
  "非ヒト霊長類を用いた霊長類三胚葉分化動態の解明に向けて"
  第21回日本再生医療学会総会, 2022/3/17.

• 髙島 康弘
  "ナイーブ型多能性幹細胞の維持培養法"
  "ナイーブ型多能性幹細胞に関する成果と可能性"
  第21回日本再生医療学会総会, 2022/3/17-18.

• Tomonori Nakamura
  "High-resolution scRNA-seq analysis of primate embryogenesis by a novel noise reduction method, "RECODE"."
  Young Researchers Symposium, THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO, 2022/3/15.

• Yasuhiro Takashima
  “Modeling in vitro embryonic development using naive pluripotent stem cells”
  Young Researchers Symposium, THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO, 2022/3/15.

• Yasuhiro Takashima
  “Modeling in vitro embryonic development using naive pluripotent stem cells”
  CiRA Symposium, Kyoto University, 2022/2/16

• 髙島 康弘
  “Studying primate early development using naïve pluripotent stem cells”
  第11回日本マーモセット研究会大会, 2022/2/2

2021

• 髙島 康弘
  “Naïve human pluripotent stem cells and human early development”
  同済大学医学部教育セミナー, 2021/12/14

• Yasuhiro Takashima
  “Analyzing human peri-implantation development using naïve pluripotent stem cells”
  ASHBi Symposium 2021, Kyoto University, 2021/11/09

• Tomonori Nakamura
  "Exploring mechanisms of primate development just after implantation."
  203rd, The Hakubi seminar, Kyoto University, 2021/9/21

• 髙島 康弘
  “ナイーブ型多能性幹細胞の運命決定とシグナル制御”
  令和3年度AMED再生・細胞医療・遺伝子治療研究開発交流会, 2021/09/08

• 中村 友紀
  "シングルセル生物学 ～生命現象理解におけるパラダイムシフト～"
  京都大学学術情報メディアセンターセミナー「シングルセル生物学とデータ解析」, 2021/8/25.

• Yasuhiro Takashima
  “Analysing human peri-implantation development using in vitro models by naïve pluripotent stem cells”
  Placental Biology Course University of Cambridge Centre for Trophoblast Research, 2021/7/5

• 髙島 康弘
  “ナイーブ型iPS細胞とヒトES/iPS細胞の運命決定とシグナル制御機構”
  第20回日本再生医療学会総会 , 2021/03/11

• Tomonori Nakamura
  "Identifying cells hidden by the curse of dimensionality"
  1st ASHBi SignAC Workshop, 2021/2/19.

• 髙島 康弘、大久保 巧
  "ナイーブ型多能性幹細胞を用いた着床期モデルの構築, Modeling in vitro embryonic development using naïve pluripotent stem cells"
  第10回日本マーモセット研究会大会, 2021/1/26.

• 渡部 聡朗, Christopher Penfold, 蝉 克憲, 岩崎 師壽江, 篠原 晴香, 髙島 康弘, Thorsten Boroviak, Knut Woltjen, 佐々木 えりか
  "マーモセット iPS 細胞からの始原生殖細胞様細胞の誘 導 mRNA-mediated induction of marmoset primordial germ cell-like cells"
  第10回日本マーモセット研究会大会, 2021/1/26-27.

シンポジウム/ワークショップ開催

• [1st Dec, 2021] 第44回日本分子生物学会年会シンポジウム主催
  「1AS-02; 非ヒト霊長類を用いた霊長類発生学研究の進展に向けて, Toward a new era for primate developmental biology 」
  Organizer: Tomonori Nakamura, Yasuhiro Takashima
  Speaker: Tomonori Nakamura, Jun Wu (University of Texas Southwestern Medical Center), Tomoyuki Tsukiyama, Toshiaki Watanabe, Jun Hatakeyama (IMEG, Kumamoto Univ), Yasuhiro Takashima.

アウトリーチ活動

• [210202] 中村 友紀、群馬県甘楽町立中学校、「進路相談会」オンライン講演